Genetically engineered pig hearts transplanted into dead people

Researchers successfully transplanted genetically modified pig hearts into two recently deceased people connected to ventilators, the New York University team announced today. The surgeries are the latest step forward in the field of animal-to-human transplants, or xenotransplantation, which has seen a flurry of successes so far this year — raising hopes for a new, steady supply of organs to ease shortages.

The only thing different about these heart transplants from a normal human-to-human heart transplant was the organ itself, the research team said in a statement. “Our goal is to integrate the practices used in a typical, everyday heart transplant, only with a nonhuman organ that will function normally without additional aid from untested devices or medicines,” said Nader Moazami, director of heart transplantation at the NYU Langone Transplant Institute.

The team performed the transplants on June 16th and July 9th, and each recipient was monitored for three days. In that time, the hearts functioned normally, and there weren’t signs of rejection from the recipients, who were connected to ventilators to keep their body processes functioning semi-regularly, even after death. The two recipients were not able to be organ donors but were able to participate in whole-body donation for this type of research.

The two pig hearts came from biotechnology company Revivicor, which produces genetically modified pigs (and also funded the research). The pigs had 10 genetic modifications — four to block pig genes and prevent rejection and six to add human genes.

A living person was successfully given a pig heart, also produced by Revivicor, in early January at the University of Maryland Medical Center. David Bennett Sr., who had severe heart disease, initially responded well to the transplant but died in March of heart failure. The specific cause is still unknown, but infection with a pig virus may have contributed to his death. The pig hearts are supposed to be free of viruses, but experts say they can be hard to detect.

The NYU team said it introduced additional virus screening protocols for its transplants. It also dedicated an operating room to xenotransplantation — that room won’t be used for any other surgical procedures.

Testing transplants on dead patients is still important even though a pig heart has already been transplanted into a living person, Robert Montgomery, the director of the NYU Langone Transplant Institute, said during a press briefing. “The focus is really on learning, studying, measuring, and trying to really unravel what is going on with this brand new, incredible technology,” he said. The team was able to take biopsies every day, for example. The research team at the University of Maryland was not able to study the transplant in as much detail because the recipient was still alive, he said.

Brain-dead patients have also been used at NYU to test kidney xenotransplantation. This fall, NYU announced that it successfully attached a pig kidney to the leg of a patient on a ventilator. The patient’s body did not reject the organ, and it functioned normally through 54 hours of observation.

Research teams are still working toward full clinical trials of xenotransplantation in living people. They’d need permission from the Food and Drug Administration to do so. The NYU team aims to extend the amount of time that they monitor a transplanted heart to collect more information to inform trials, Montgomery said in the press briefing. He thinks that clinical trials could start sometime between now and 2025. Revivicor said in April that it’s hoping to start clinical trials in the next year or two.

There’s still a lot to learn about xenotransplantation and a lot to figure out about the ethical implications of animal-to-human procedures. But if they work, they could offer a new option to the thousands of people on wait lists for organs.

“Xenotransplantation, I believe, offers the best chance for a renewable, sustainable source of organs so that no one will have to die waiting for an organ,” Montgomery said.

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